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Metabolic response to infection.

W R Beisel

    Annual Review of Medicine
    |January 1, 1975
    PubMed
    Summary

    Infections trigger complex host metabolic changes. These responses aid homeostasis, energy provision, and acute-phase protein synthesis during illness.

    Area of Science:

    • Host-pathogen interactions
    • Immunometabolism
    • Physiological responses to infection

    Background:

    • Infectious processes induce diverse host metabolic alterations.
    • Some responses are direct consequences of microbial interactions or host defenses.
    • Other responses, less understood, involve systemic mediators and tissues.

    Purpose of the Study:

    • To elucidate the multifaceted metabolic responses in hosts during generalized infections.
    • To differentiate direct versus indirectly mediated metabolic changes.
    • To understand the role of endogenous mediators in infection-related metabolism.

    Main Methods:

    • Analysis of host metabolic pathways during infection.
    • Investigation of cellular interactions with microorganisms and their products.

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  • Study of host defensive mechanisms and their metabolic impact.
  • Identification of hormonal-like endogenous mediators regulating metabolic shifts.

    • Main Results:

    • Identified direct causal links between microbial interactions/host defenses and specific metabolic changes.
    • Characterized systemic metabolic responses regulated by endogenous mediators.
    • Demonstrated contribution of these responses to homeostasis, energy supply, and acute-phase protein synthesis.

    Conclusions:

    • Generalized infections elicit a complex spectrum of host metabolic responses.
    • Both direct and mediator-regulated pathways are crucial for host adaptation.
    • These metabolic adjustments are vital for maintaining homeostasis and combating infection.