[Histological evaluation of activity and progression changes in the liver in HCV infected children]

In this study we present the analysis of pathological pictures of the liver in children with chronic HCV infection, among whom 60 children with HCV RNA and 22 children without HCV RNA were selected. For histological evaluation traditional classification and modified Histological Activity Index (HAI) was used. Only 2 children without viremia did not present changes in histopathological picture, in the remaining ones with and without viremia hepatitis chronic persistent prevailed. In both groups of children statistical differences in necroinflammatory activity and fibrosis were not observed. In histopathological picture correlation grading and staging was observed. The results of the studies show necessity for histological evaluation in anti-HCV carriers, because the pathology of the liver may occur independent of viremia.