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Glibenclamide induced chronic cholestasis simulating primary biliary cirrhosis: a case report
M Ramanathan1, S Wahinuddin, S T Kew
1Department of Medicine, Taiping Hospital, Perak.
The Medical Journal of Malaysia
|March 1, 1996
Summary
Drug-induced chronic cholestasis (DICC) from glibenclamide can mimic primary biliary cirrhosis (PBC). Withdrawal of the drug led to spontaneous recovery, confirming DICC.
Area of Science:
- Hepatology
- Clinical Pharmacology
Background:
- Non-insulin dependent diabetes mellitus management often involves oral hypoglycemic agents.
- Cholestatic liver disease presents a diagnostic challenge, potentially mimicking autoimmune or biliary conditions.
Observation:
- A 43-year-old female patient with diabetes mellitus developed cholestatic liver disease.
- Initial diagnosis considered primary biliary cirrhosis (PBC).
Findings:
- The patient's condition resolved spontaneously after discontinuing glibenclamide.
- This outcome indicated drug-induced chronic cholestasis (DICC) rather than PBC.
- Key differences between PBC and DICC were identified.
Implications:
- Glibenclamide should be considered as a potential cause of drug-induced liver injury, specifically cholestasis.
- Distinguishing DICC from PBC is crucial for appropriate patient management and treatment.
- Awareness of drug-induced liver disease is essential in clinical practice.
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