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Longitudinal growth in HIV-negative boys with haemophilia
1Department of Paediatrics, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic.
Insights
Growth in children with hemophilia (an inherited bleeding disorder) is not impacted by the condition itself, even with treatment or joint bleeding. This study analyzed growth data in HIV-negative hemophilic patients.
Area of Science:
- Pediatrics
- Hematology
- Endocrinology
Background:
- Human immunodeficiency virus (HIV)-positive children with hemophilia often exhibit growth retardation.
- Factors beyond HIV infection may influence growth in these children.
- Understanding growth patterns in HIV-negative hemophilic patients is crucial.
Purpose of the Study:
- To analyze growth data in HIV-negative hemophilic patients.
- To determine if hemophilia severity or treatment center affects growth.
- To assess the impact of bleeding episodes and therapy on growth.
Main Methods:
- Longitudinal cross-sectional analysis of growth data.
- Inclusion of 84 HIV-negative hemophilic patients from two university clinics.
- Collection of height and weight measurements (2-24 per patient) between 1977-1995.
Main Results:
- Mean height Standard Deviation Score (SDS) was -0.31 and Body Mass Index (BMI) SDS was 0.21 at first measurement.
- Height and BMI remained unchanged throughout the observation period.
- No significant differences in height or BMI were observed based on hemophilia severity or study center.
Conclusions:
- Growth in HIV-negative patients with hemophilia is not affected.
- Immunological abnormalities from substitution therapy do not impede growth.
- Bleeding episodes in joints do not appear to impact the growth plate in these patients.
Unlabelled:
It has been shown that HIV-positive haemophilic children develop growth retardation. As not only the HIV infection but also other disease-related factors might compromise growth in these children, growth data were analysed in a longitudinal cross-sectional manner in 84 HIV-negative haemophilic patients from two university clinics. A total of 2-24 height and weight measurements (median 6) were recorded in each patient resulting in 683 single values collected between 1977-1995. Height SDS of all haemophilic boys was -0.31 +/- 2.13 (mean +/- SD, NS versus 0) and body mass index SDS was 0.21 +/- 3.49 (mean SD, NS versus 0) at first measurement and remained unchanged throughout the observation period. Neither height nor body mass index differed with respect to the severity of haemophilia (mild/moderate/severe) or the study centre (Vienna/Prague).
Conclusion:
Growth in HIV-negative patients with haemophilia is not affected in spite of the immunological abnormalities attributed to the substitution therapy or the bleeding episodes in the joints with the potential effect on the growth plate.