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Related Experiment Videos

New developments in viral peptides and APL induction.

A E Gharavi1, S S Pierangeli, E N Harris

  • 1Department of Medicine, Morehouse School of Medicine, Atlanta, GA 30310-1495, USA. aghara@pol.net

Journal of Autoimmunity
|September 2, 2000
PubMed
Summary

Pathogenic antiphospholipid antibodies (aPL) can be induced by foreign beta(2)-GPI or viral peptides. These antibodies cause fetal death and spinal cord infarction in mice, suggesting microbial triggers in antiphospholipid syndrome.

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Area of Science:

  • Immunology
  • Pathology
  • Autoimmunity

Background:

  • Antiphospholipid antibodies (aPL) are linked to thrombosis and fetal death.
  • The mechanisms inducing pathogenic aPL production remain unclear.

Purpose of the Study:

  • To investigate the induction and pathogenic mechanisms of antiphospholipid antibodies (aPL).
  • To explore potential microbial triggers for aPL production in antiphospholipid syndrome (APS).

Main Methods:

  • Immunization of mice with beta(2)-GPI and synthetic peptides.
  • Induction of aPL using viral peptides.
  • Assessment of pathogenic effects including fetal death and spinal cord infarction.
  • In vitro endothelial cell activation assays.

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Main Results:

  • Immunization with foreign beta(2)-GPI or specific peptides induced pathogenic aPL.
  • Induced aPL caused intrauterine fetal death and spinal cord infarction in mice.
  • Viral peptide immunization also led to pathogenic aPL and adverse effects.
  • Activated endothelial cells in vitro.

Conclusions:

  • Pathogenic aPL can be induced by beta(2)-GPI or microbial-derived peptides.
  • These findings suggest that bacterial or viral products may trigger aPL in APS patients.
  • Microbial mimicry could be a key mechanism in the pathogenesis of APS.