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Related Experiment Videos

Association entropy in adsorption processes.

N Ben-Tal1, B Honig, C K Bagdassarian

  • 1Department of Biochemistry, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Israel. bental@ashtoret.tau.ac.il

Biophysical Journal
|September 2, 2000
PubMed
Summary
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Adsorption involves entropy loss, converting free motion to bound states. This study quantizes adsorption entropy, finding it less than binding entropy due to softer potentials and fewer restricted degrees of freedom.

Area of Science:

  • Thermodynamics
  • Statistical Mechanics
  • Biophysics

Background:

  • Molecular association, like ligand-protein binding or peptide-membrane adsorption, results in entropy loss.
  • Previous estimates for binding entropy change (DeltaS(o)) suggested significant losses (approx. -50 e.u.).
  • This study focuses on adsorption entropy, differentiating it from binding processes.

Purpose of the Study:

  • To develop a statistical-thermodynamic model for calculating adsorption entropy.
  • To resolve adsorption entropy into translational and rotational contributions.
  • To calculate the adsorption entropy of pentalysine on a lipid membrane.

Main Methods:

  • Developed a statistical-thermodynamic scheme for adsorption entropy calculation.
  • Utilized distance-orientation dependent adsorption potentials.

Related Experiment Videos

  • Applied the scheme to model pentalysine adsorption onto a lipid membrane.

    • Main Results:

    • Calculated adsorption entropy (TDeltaS(o)) for pentalysine on a lipid membrane as approximately -1.7 kT.
    • Identified the primary contribution to entropy loss from restricting one translational degree of freedom.
    • Found adsorption entropy loss to be significantly smaller than typical binding entropy loss.

    Conclusions:

    • Adsorption involves a smaller entropy loss compared to binding processes.
    • This difference is attributed to fewer restricted degrees of freedom and softer adsorption potentials.
    • The developed scheme provides a method to quantify adsorption entropy and its components.