Related Experiment Videos
The relationship between gastroesophageal reflux and apnea in infants
N Arad-Cohen1, A Cohen, E Tirosh
1Jacobo Lichtman Apnea Investigation Unit, Department of Pediatrics, Bnai Zion Medical Center, Technion, Israel.
Insights
Apnea and gastroesophageal reflux (GER) are seldom linked in infants experiencing apparent life-threatening events. When associated, obstructive apnea typically precedes reflux.
Area of Science:
- Pediatric Medicine
- Neonatology
- Gastroenterology
Background:
- Apparent life-threatening events (ALTEs) in infants are concerning clinical events.
- Gastroesophageal reflux (GER) is a potential contributing factor to ALTEs.
Purpose of the Study:
- To investigate the prevalence and relationship between apnea and GER in infants with ALTEs.
Main Methods:
- Sixty-seven infants (up to 6 months) with idiopathic ALTEs were evaluated.
- Polysomnography and pH monitoring were used to assess apnea and GER.
Main Results:
- No GER was observed in 32 infants; 14 had unassessable reflux.
- In the 21 infants with both apnea and GER, 81% showed no relationship.
- Apnea preceded reflux in 93.6% of associated episodes, primarily obstructive or mixed apnea.
Conclusions:
- Apnea and GER are infrequently associated in infants with ALTEs.
- When linked, obstructive or mixed apnea typically precedes GER episodes.
Objective:
To determine the prevalence and relationship between apnea and gastroesophageal reflux (GER) among infants with apparent life-threatening events.
Methods:
We evaluated 67 infants of ages up to 6 months who had an idiopathic apparent life-threatening event as determined by polysomnography and pH monitoring.
Results:
No reflux (pH < 4 for more than 6 seconds) was evident in 32 infants. Fourteen others had such prolonged reflux that the relationship between apnea and reflux could not be evaluated. The 21 remaining infants who had episodes of apnea and reflux constituted the study group. In 81% of the apneic episodes, no relationship to GER was noted. Apnea preceded reflux in 93.6% of the episodes, and only 6.4% of the apneic episodes followed reflux. When apnea preceded reflux, the apnea was obstructive in 66.8% of episodes and mixed in 33.2%. Central apnea was not recorded preceding reflux.
Conclusions:
Episodes of apnea were seldom associated with GER. However, in those instances when apnea and reflux were associated, the predominant sequence of events was obstructive apnea and to a lesser extent mixed apnea followed by reflux.