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[Stabilizing the course of patients with stage IV advanced malignant melanoma by trofosfamide treatment]
Abstract
Background And Objective:
Stage IV melanoma patients with progressive disease are a therapeutic challenge for every dermatologist. We wondered whether a mild oral chemotherapy with trofosfamide would ameliorate disease progression in these patients.
Patients/Methods:
40 patients with melanoma (stage IV disease) were treated with 100 mg/day of trofosfamide for 6 months. All patients showed a progressive disease prior to this intervention.
Results:
One patient experienced a partial remission, 25 patients showed a stable disease. Only 11 patients were progressive under trofosfamide treatment. 7 patients died during the study period.
Conclusions:
Therapy with trofosfamide seems to ameliorate disease progression in stage IV patients.