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Published on: March 26, 2018
Interventions associated with minimal fontan mortality
G S Van Arsdell1, B W McCrindle, K D Einarson
1Division of Cardiovascular Surgery, The Hospital for Sick Children and the University of Toronto, Ontario, Canada. glen.vanarsdell@sickkids.on.ca
Insights
The Fontan procedure
Area of Science:
- Pediatric Cardiology
- Cardiac Surgery
- Congenital Heart Disease
Background:
- The Fontan procedure is a complex surgical intervention for congenital heart defects.
- Initial operative mortality rates were high (15%) but improved significantly over time.
Purpose of the Study:
- To investigate factors associated with the observed decline in Fontan procedure mortality.
- To identify interventions contributing to improved patient outcomes.
Main Methods:
- Retrospective review of 100 consecutive Fontan procedure cases.
- Comparison of patient characteristics and perioperative management between early and later cohorts.
Main Results:
- Mortality decreased from 16% to 0% between the first and second 50 patients.
- Increased use of extracardiac Fontan, prior cavopulmonary anastomosis, shorter bypass times, magnesium-rich cardioplegia, and post-bypass ultrafiltration were noted in the lower-mortality group.
- No significant differences in patient age, diagnosis, or surgeon were found.
Conclusions:
- Patient factors did not explain the mortality reduction.
- Specific surgical techniques and perioperative management strategies, including extracardiac Fontan and modified ultrafiltration, are linked to reduced mortality.
- These interventions may enhance postoperative myocardial function.
Background:
The operative mortality rate for the first 400 Fontan procedures at this institution was 15% but declined to 4% for the next 100 procedures.
Methods:
The cases of 100 consecutive patients receiving the Fontan procedure and associated with this change in mortality rate were reviewed to determine associations.
Results:
The mortality rate in the first and second 50 patients was 16% and 0%, respectively. There were no differences in age, number of risk factors, diagnosis, or operating surgeon between the two groups. Patients in the lower-mortality era were significantly more likely to have had a cavopulmonary anastomosis before a Fontan procedure (90% versus 70%) and to have an extracardiac Fontan procedure (38% versus 8%), shorter cross-clamp (45+/-24 minutes versus 58+/-22 minutes) and cardiopulmonary bypass times (121+/-42 minutes versus 141+/-45 minutes), magnesium-rich cardioplegia (100% versus 39%), hemoconcentration after bypass (67% versus 4%), and institution of pharmacologic support in the operating room.
Conclusions:
Patient characteristics and risk factors were similar in the two groups. However, several interventions that were increasingly utilized in the lower-mortality era, including the extracardiac Fontan procedure and modified ultrafiltration after bypass, are associated with lower mortality. Each one had the potential to improve postoperative myocardial function.
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