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Strongyloidiasis--progress in diagnosis and treatment.

O Zaha1, T Hirata, F Kinjo

  • 1First Department of Internal Medicine, Faculty of Medicine, University of Ryukyus, Okinawa.

Internal Medicine (Tokyo, Japan)
|September 2, 2000
PubMed
Summary

Diagnosing intestinal parasitic disease strongyloidiasis is improved by a new agar plate culture method. Ivermectin is the most effective and safest treatment for strongyloidiasis, surpassing other drugs.

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Area of Science:

  • Medical Parasitology
  • Infectious Diseases
  • Gastroenterology

Background:

  • Strongyloidiasis is an intestinal parasitic disease caused by Strongyloides stercoralis.
  • Accurate diagnosis and effective treatment are crucial for managing strongyloidiasis.
  • Current diagnostic methods and treatments have limitations.

Purpose of the Study:

  • To evaluate a new agar plate culture method for diagnosing strongyloidiasis.
  • To compare the efficacy and safety of different chemotherapeutic agents for strongyloidiasis treatment.

Main Methods:

  • Development and application of an ordinary agar plate culture method for detecting Strongyloides stercoralis larvae in feces.
  • Clinical study evaluating thiabendazole, mebendazole, albendazole, and ivermectin in patients with strongyloidiasis.

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Main Results:

  • The agar plate culture method is simpler, more sensitive, and more useful for diagnosis and evaluating treatment efficacy than the filter paper culture method.
  • Thiabendazole, while effective, has significant safety concerns including adverse effects and liver dysfunction.
  • Mebendazole also showed a high incidence of liver dysfunction, and albendazole had insufficient eradicating effects.
  • Ivermectin demonstrated a strong anthelmintic effect with the least toxicity among the studied drugs.

Conclusions:

  • The ordinary agar plate culture method is a highly useful diagnostic tool for strongyloidiasis.
  • Ivermectin is considered the most useful drug for treating strongyloidiasis due to its efficacy and favorable safety profile.