Related Experiment Videos
Synthesis and monoamine transporter affinity of 2beta-carbomethoxy-3beta-(2''-, 3''- or 4''-substituted)
G Tamagnan1, R M Baldwin, N S Kula
1Yale University, School of Medicine, VA Connecticut HCS, West Haven, CT 06516, USA. gilles.tamagnan@yale.edu
Bioorganic & Medicinal Chemistry Letters
|September 2, 2000
Abstract:
A series of 11 novel 3beta-substituted biphenyltropanes was synthesized and evaluated by selective radioligand binding assays for affinity to monoamine transporters. Both 5-HTT potency and selectivity for 5-HTT over DAT was greatest with electron withdrawing group at the 3''-position.