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The total synthesis of piclavines A1-4 and their biological evaluation
1Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University, Sugitani, Japan. takahata@ms.toyama-mpu.ac.jp
Bioorganic & Medicinal Chemistry Letters
|September 2, 2000
Abstract:
The total synthesis of piclavines A1, A2, A3, and A4 has been achieved starting from compound 10 with enantiomeric enhancement. Their biological activities (antibacterial, antimicrobacterial, and antiviral activities and inhibition of cell growth) were evaluated.