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The mammalian gene mutation database.

P D Lewis1, J S Harvey, E M Waters

  • 1Centre for Molecular Genetics and Toxicology, School of Biological Sciences, University of Wales Swansea, Swansea SA2 8PP, UK. balewis@swan.ac.uk

Mutagenesis
|September 2, 2000
PubMed
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The Mammalian Gene Mutation Database (MGMD) offers a vast collection of mutation data for mammalian gene models. This resource aids genetic toxicologists by standardizing mutation reporting and providing user-friendly data access.

Area of Science:

  • Genetics
  • Toxicology
  • Bioinformatics

Background:

  • Mutation data is crucial for understanding genetic toxicology.
  • Existing literature lacks a standardized, accessible repository for mammalian gene mutation data.

Purpose of the Study:

  • To establish a comprehensive, internet-accessible database of mammalian gene mutation data.
  • To standardize the reporting of mutations across different genes.
  • To provide a user-friendly tool for accessing and analyzing mutation spectra.

Main Methods:

  • Compilation of published mutation data from the open literature.
  • Development of a multi-option search facility for mutagen, gene, and cell type.
  • Daily maintenance and updates of the database records.

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Main Results:

  • The Mammalian Gene Mutation Database (MGMD) contains approximately 30,000 described mutant spectra records.
  • The database is accessible online and features interactive, user-friendly data retrieval.
  • A multi-option search function allows targeted data exploration.

Conclusions:

  • The MGMD serves as a valuable reference source for genetic toxicologists.
  • The database facilitates the analysis of mutation data for various applications.
  • Standardized reporting and accessible data enhance research in mammalian mutagenesis.