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Updated: Aug 10, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
Published on: March 17, 2020
[Failure of bone marrow autograft in metastatic malignant adrenalcortical carcinoma]
E Andrès1, J E Kurtz, B Lioure
1Service de Médecine Interne et Nutrition, Hôpital de Hautepierre, Strasbourg. medecineinterne.chuhautepierre@wanadoo.fr
Background:
Despite different therapeutic modalities (surgery, hormones therapy, chemotherapy), 5-year survival in patients with malignant adrenocortical carcinoma remains only 10% to 20%. Bone marrow grafts may be proposed to intensify treatment.
Case Report:
In a 29-year-old patient with adrenocortical carcinoma with metastases to the lung and bone, an adjuvant bone marrow graft using peripheral stem cells was unsuccessful. Recurrence was observed at 3 months and overall survival was 2 years.
Discussion:
Our case illustrates the feasibility of this approach but also emphasizes the relatively poor results obtains with only 2 years survival (1 year after the bone marrow graft), comparable with other classical modalities reported in the literature.
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