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Updated: Jul 12, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
Published on: August 25, 2021
Expressions of various growth factors and their receptors in tissues from neurofibroma
T Kadono1, K Kikuchi, H Nakagawa
1Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Background:
Platelet-derived growth factor BB (PDGF-BB) and transforming growth factor beta are known to enhance the growth of neurofibroma-derived cells from neurofibromatosis type 1 (NF-1) patients.
Objective:
This study aims to elucidate whether these growth factors and their receptors are up-regulated in NF-1 patients.
Methods:
Tissues and culture cells from neurofibroma in NF-1 patients, nontumor lesions in NF-1 patients, and the skin of normal controls were collected. To evaluate the expressions of growth factors and their receptors, reverse-transcriptase polymerase chain reaction and immunohistochemistry were performed.
Results:
PDGF-beta receptor subunit was expressed in the neurofibroma tissues from NF-1 patients, but not in the nontumorous tissues from NF-1 patients or skin from normal controls. As for the other factors, there were no significant differences among these tissues. Neurofibroma sections also stained positive for the PDGF-beta receptor subunit.
Conclusions:
The interaction of PDGF and PDGF-beta receptor subunit may be important in the tumorigenesis of NF-1.
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