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Related Experiment Videos

Reducing electrostatic charge on spacer devices and bronchodilator response.

J H Wildhaber1, G W Waterer, G L Hall

  • 1Departments of Respiratory Medicine, University Children's Hospital, 8032 Zürich, Switzerland. johannes.wildhaber@kispi.unizh.ch

British Journal of Clinical Pharmacology
|September 6, 2000
PubMed
Summary

Washing plastic spacers with detergent significantly improved bronchodilator response in adult asthma patients. This simple cleaning method enhances medication delivery from pressurized metered dose inhalers (pMDIs).

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Area of Science:

  • Respiratory Medicine
  • Pharmacology
  • Medical Devices

Background:

  • Plastic spacers are commonly used with pressurized metered dose inhalers (pMDIs) to improve drug delivery.
  • Reducing electrostatic charge on spacers via detergent washing enhances in vitro and in vivo drug delivery.
  • The clinical impact of this electrostatic charge reduction on bronchodilator response in asthma patients remains to be fully elucidated.

Purpose of the Study:

  • To assess if reducing electrostatic charge on a plastic spacer by washing it with detergent improves bronchodilator response in adult asthmatics.
  • To determine the effect of a cleaned spacer on salbutamol delivery and efficacy.
  • To investigate the clinical significance of spacer preparation on asthma medication effectiveness.

Main Methods:

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  • Twenty adult asthma patients with known bronchodilator response participated in the study.
  • Salbutamol was administered via pMDI (Ventolin) using both an untreated new spacer (Volumatic) and a detergent-washed spacer in a randomized order.
  • Doses of salbutamol ranged from 100 to 800 microg, with spirometry, heart rate, and blood pressure monitored throughout the study.

    • Main Results:

    • No significant difference in baseline forced expiratory volume in 1 second (FEV1) was observed between the untreated and detergent-washed spacers.
    • The provocation dose required to achieve a 10% improvement in FEV1 (PD10) was significantly lower with the detergent-washed spacer (430 microg vs. 1505 microg).
    • This indicates a more efficient bronchodilator response when using a cleaned spacer.

    Conclusions:

    • Washing plastic spacers with household detergent improves bronchodilator response in adult asthmatics.
    • Reducing electrostatic charge on spacers enhances the clinical effectiveness of asthma medication delivered via pMDI.
    • The choice and preparation of the delivery device are crucial for optimizing asthma treatment outcomes.