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Schnitzler's syndrome: no evidence for autoimmune basis in two patients
R Gallo1, R A Sabroe, A K Black
1Professorial Unit, St. John's Institute of Dermatology, St. Thomas's Hospital, London, UK.
Abstract:
We report two cases of Schnitzler's syndrome in which anti-interleukin-1alpha autoantibodies and functional autoantibodies against the high affinity IgE receptor (FcepsilonRIalpha) or against IgE were absent. One patient responded well to TL-01 phototherapy, a treatment which may be considered in patients with Schnitzler's syndrome if, as is usually the case, they are unresponsive to antihistamine therapy.
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