Toxin-mediated haemolytic uraemic syndrome without diarrhoea

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A P Kater1, A M Westermann, M R de Groot

  • 1Departments of Internal Medicine, Haematology and Medical Microbiology, Academic Medical Centre, Amsterdam, The Netherlands. APhkater@yahoo.com

Journal of Internal Medicine
|September 6, 2000
PubMed

A 52-year-old previously healthy man was admitted to the hospital with haematuria, painful micturition and fever. Laboratory investigation showed the presence of a haemolytic uraemic syndrome (HUS), characterized by haemolysis, renal insufficiency and mental disturbances. A urinary tract infection caused by a verotoxin-producing E. coli other than O157:H7 was diagnosed. Treatment of this infection resulted in his complete recovery from the illness. Both the search for a focus outside the gastrointestinal tract and the search for verotoxin genes by specific polymerase chain reaction can be crucial in a patient with HUS without preceding diarrhoea.

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