Osteosarcoma in a sixteen-month old boy
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Updated: Oct 13, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
Published on: October 14, 2016
S Ibrahim1, M N Sundari, N Masir
1Department of Orthopaedic and Traumatology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur.
Insights
This report details the youngest known case of osteosarcoma in Malaysia, diagnosed in a sixteen-month-old boy. The aggressive nature of this rare pediatric bone cancer led to rapid disease dissemination and fatality within six weeks.
Area of Science:
- Pediatric Oncology
- Skeletal Malignancies
Background:
- Osteosarcoma is a rare primary malignant bone tumor.
- It most commonly affects adolescents and young adults.
- Occurrence in very young children is exceptionally rare.
Observation:
- A sixteen-month-old boy presented with osteosarcoma of the left humerus.
- This represents the youngest reported case in Malaysia.
- The patient exhibited rapid disease progression.
Findings:
- The pediatric patient was diagnosed with localized osteosarcoma.
- The tumor was located in the left humerus.
- Disseminated disease was evident shortly after diagnosis.
Implications:
- Highlights the occurrence of osteosarcoma in extremely young pediatric patients.
- Underscores the aggressive potential and rapid progression of the disease in this age group.
- Emphasizes the need for early detection and aggressive management strategies for pediatric osteosarcoma.
Abstract:
We report a case of a sixteen-month old boy with osteosarcoma of the left humerus. To the best of our knowledge this is the youngest case reported in Malaysia. This case illustrates that osteosarcoma although rare does occur in a very young child. The child died six weeks after presentation due to disseminated disease.
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