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[Blistering drug reactions].

J C Roujeau1

  • 1Service de dermatologie Hôpital Henri-Mondor, Créteil. jean-claude.roujeau@hmn.ap-hop-paris.fr

La Revue Du Praticien
|September 6, 2000
PubMed
Summary

Blistering drug eruptions, including severe Stevens-Johnson syndrome and Toxic epidermal necrolysis, signal serious adverse drug reactions. This review covers their clinical signs, histology, causes, and outcomes.

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Area of Science:

  • Dermatology
  • Pharmacology
  • Pathology

Context:

  • Adverse drug reactions (ADRs) can manifest with severe mucocutaneous findings.
  • Blistering eruptions on skin and mucous membranes are critical indicators of ADR severity.

Purpose:

  • To review the clinical and histological presentation of blistering drug eruptions.
  • To identify common and severe drug causes of these reactions.
  • To discuss the prognosis of Stevens-Johnson syndrome and Toxic epidermal necrolysis.

Summary:

  • Blistering drug eruptions, characterized by skin blisters and/or mucosal erosions, represent significant adverse drug reactions.
  • This review details the clinical features, histological findings, causative agents, and outcomes associated with these eruptions.
  • Special emphasis is placed on the most severe forms: Stevens-Johnson syndrome (SJS) and Toxic epidermal necrolysis (TEN).

Impact:

  • Improved recognition and diagnosis of severe drug reactions.
  • Enhanced understanding of the pathogenesis and clinical course of SJS and TEN.
  • Guidance for clinicians in managing patients with blistering drug eruptions.

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