R factor in Enterobacter cloacae resistant to silver sulfadiazine
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Chemotherapy
|January 1, 1975
Abstract:
A strain of Enterobacter cloacae resistant to silver sulfadiazine was recovered from a unit in which this antimicrobial agent was in use. This strain was found to harbor an R factor responsible for resistance to carbenicillin, kanamycin and ampicillin. These antibiotic resistances were transferable to Escherichia coli by mating. Resistance to silver sulfadiazine was not, however, transmissible.
Insights
A novel strain of Enterobacter cloacae resistant to silver sulfadiazine was identified. While carrying transferable antibiotic resistance, the silver sulfadiazine resistance itself was not passed between bacteria.
Area of Science:
- Microbiology
- Antimicrobial Resistance
Background:
- Silver sulfadiazine is a topical antimicrobial agent widely used in clinical settings.
- The emergence of antimicrobial resistance poses a significant threat to public health.
Purpose of the Study:
- To investigate the characteristics of a silver sulfadiazine-resistant Enterobacter cloacae strain.
- To determine the transmissibility of silver sulfadiazine resistance.
Main Methods:
- Isolation and identification of Enterobacter cloacae from a clinical unit.
- Phenotypic testing for antimicrobial susceptibility.
- Conjugation experiments to assess resistance transfer.
Main Results:
- A strain of Enterobacter cloacae exhibiting resistance to silver sulfadiazine was isolated.
- This strain also possessed an R factor conferring resistance to carbenicillin, kanamycin, and ampicillin.
- These antibiotic resistances were transferable to Escherichia coli via conjugation.
Conclusions:
- Enterobacter cloacae can develop resistance to silver sulfadiazine.
- While other antibiotic resistances were transferable, silver sulfadiazine resistance was not found to be transmissible in this study.