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A High-throughput Shigella-specific Bactericidal Assay
06:11

A High-throughput Shigella-specific Bactericidal Assay

Published on: February 27, 2019

Shigella strains associated with infantile diarrhea in the Kaohsiung area

C F Peng

    Zhonghua Minguo Wei Sheng Wu Xue Za Zhi = Chinese Journal of Microbiology
    |March 1, 1975
    PubMed

    Insights

    This study tracked Shigella strains in Kaohsiung, finding Shigella sonnei and Shigella flexneri predominated. High antimicrobial resistance was observed in these common bacterial causes of infant diarrhea.

    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Public Health

    Background:

    • Shigellosis is a significant cause of infantile diarrhea, particularly in developing regions.
    • Understanding the epidemiology and antimicrobial susceptibility patterns of Shigella is crucial for effective treatment and control.

    Purpose of the Study:

    • To investigate the serotypes and antimicrobial susceptibility of Shigella strains isolated from diarrheal cases in Kaohsiung.
    • To identify predominant Shigella serotypes and track changes over time (1969-1974).
    • To assess the in vitro resistance of Shigella sonnei and Shigella flexneri to various antimicrobial agents.

    Main Methods:

    • Isolation and serotyping of 375 Shigella strains from diarrheal cases in Kaohsiung (1969 and 1974).
    • Colicine typing was performed on Shigella sonnei isolates.
    • In vitro antimicrobial susceptibility testing was conducted against 10 different agents.

    Main Results:

    • Shigella sonnei and Shigella flexneri type 2 were the most prevalent serotypes, with an increasing trend for S. sonnei in 1974.
    • Commonly isolated S. sonnei strains belonged to colicine types 8, 6, and 12.
    • High resistance rates were observed for S. flexneri and S. sonnei against chloramphenicol, streptomycin, and tetracycline.

    Conclusions:

    • Shigella sonnei and Shigella flexneri are key pathogens in Kaohsiung's infantile diarrhea cases.
    • Significant antimicrobial resistance, especially to older antibiotics, necessitates careful treatment selection.
    • Ongoing surveillance of Shigella serotypes and resistance patterns is vital for public health interventions.

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