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Updated: Jul 23, 2026

Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
Published on: February 4, 2017
The quantification of technetium in generator-derived pertechnetate using ICP-MS
D M Hill1, R K Barnes, H K Wong
1Australian Nuclear Science and Technology Organisation Menai, NSW.
Abstract:
Previous analytical methods employed to measure 99Tc:99mTc ratios in chromatographic 99mTc generators, derived from fission-based 99Mo, were limited in monitoring the ratios in low activity generators, over the extent of their elution regimes. For regulatory purposes, ICP-MS was employed to measure total technetium in generator eluates down to a level of 200 pg ml(-1) (200 ppt). Measured 99Tc:99mTc ratios compared very well with the theoretically computed values, ranging from 47:1 for a first elution of a generator with a long ingrowth time to 1.4:1 for the 17th elution of a generator with a short ingrowth time.
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