Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Catecholamines and drug-behavior interactions.

L S Seiden, R C MacPhail, M W Oglesby

    Federation Proceedings
    |August 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Episodic ozone exposure in adult and senescent Brown Norway rats: acute and delayed effect on heart rate, core temperature and motor activity.

    Inhalation toxicology·2014
    Same author

    Ozone induces glucose intolerance and systemic metabolic effects in young and aged Brown Norway rats.

    Toxicology and applied pharmacology·2013
    Same author

    Susceptibility of adult and senescent Brown Norway rats to repeated ozone exposure: an assessment of behavior, serum biochemistry and cardiopulmonary function.

    Inhalation toxicology·2013
    Same author

    Acute administration of dopaminergic drugs has differential effects on locomotion in larval zebrafish.

    Pharmacology, biochemistry, and behavior·2013
    Same author

    Toluene effects on the motor activity of adolescent, young-adult, middle-age and senescent male Brown Norway rats.

    Neurotoxicology·2011
    Same author

    Assessing locomotor activity in larval zebrafish: Influence of extrinsic and intrinsic variables.

    Neurotoxicology and teratology·2011

    Drug effects on behavior depend on response rates. Operant behavior alters brain catecholamine metabolism, influencing drug responses and suggesting a neurochemical mechanism for these rate-dependent effects.

    Area of Science:

    • Neuroscience
    • Behavioral Pharmacology
    • Psychopharmacology

    Background:

    • Drug effects on operant behavior are rate-dependent.
    • Catecholamines are crucial for behavior maintenance.
    • Drug-behavior interactions may involve central nervous system catecholamine metabolism.

    Purpose of the Study:

    • To investigate the neurochemical mechanisms underlying rate-dependent drug effects.
    • To determine if operant behavior alters catecholamine metabolism.
    • To explore variables influencing performance-induced changes in catecholamine metabolism.

    Main Methods:

    • Measuring catecholamine depletion after synthesis inhibition with alpha-methyl-para-tyrosine (alphaMT).
    • Assessing changes in norepinephrine specific activity using tritium labeling.

    Related Experiment Videos

  • Analyzing variables such as response rate, reinforcement rate/density, and response-reinforcer contingencies.

    • Main Results:

    • Operant behavior significantly alters brain catecholamine metabolism.
    • Specific variables like response rate and reinforcement density influence these metabolic changes.
    • Evidence suggests a neurochemical basis for the rate-dependent effects of amphetamine and alphaMT.

    Conclusions:

    • Operant behavior modulates catecholamine metabolism, impacting subsequent drug effects.
    • A neurochemical model is proposed to explain drug-behavior interactions.
    • Findings provide insight into the mechanisms of psychopharmacological drug action.