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Clinical and laboratory parameters in dapsone acute intoxication
M Z Carrazza1, F R Carrazza, S Oga
1Programa de Controle de Intoxicações, Secretaria de Saúde do Município de São Paulo, São Paulo, SP, Brasil. carraz@usp.br
Revista De Saude Publica
|September 6, 2000
Summary
Dapsone (DDS) acute intoxication severity was assessed using clinical and lab data. Methemoglobinemia and dapsonemia levels correlated significantly with DDS intake, aiding in determining intoxication severity.
Area of Science:
- Toxicology
- Clinical Pharmacology
- Emergency Medicine
Background:
- Dapsone (DDS) acute intoxication is an uncommon but serious medical event.
- Clinical and laboratory parameters are crucial for assessing DDS toxicity severity.
Purpose of the Study:
- To determine the severity of dapsone (DDS) acute intoxication.
- To correlate clinical signs with laboratory parameters in DDS intoxication.
Main Methods:
- Studied 274 patients (1 month to 50 years) with acute DDS intoxication.
- Classified patients into four age groups for analysis.
- Used spectrophotometric methods to measure methemoglobinemia (MHbp) and dapsonemia (DDSp).
Main Results:
- Cyanosis was the most frequent sign (65.7%), especially in children under 5 (100%).
- Severe intoxication was identified in 56.2% by MHbp and 58% by DDSp.
- Significant correlations were found between MHbp, DDSp, and time since DDS intake.
Conclusions:
- A significant association exists between methemoglobinemia and time elapsed after DDS intake.
- Developed an equation to predict dapsonemia based on time and methemoglobinemia levels.
- Clinical and laboratory findings aid in managing DDS acute intoxication.
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