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Related Experiment Videos

Adrenocortical function in experimental protein malnutrition.

J S Bajaj, R Khardori, M G Deo

    Metabolism: Clinical and Experimental
    |May 1, 1979
    PubMed
    Summary
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    Protein deficiency in Rhesus monkeys elevates adrenocorticoid activity, causing sustained steroidogenesis and abolishing diurnal cortisol rhythms. This heightened stress response may impair immune defense against infections.

    Area of Science:

    • Endocrinology
    • Nutritional Science
    • Primate Research

    Background:

    • Protein malnutrition is a significant global health concern.
    • Its impact on endocrine function, particularly adrenocorticoid activity, requires further elucidation.
    • Understanding these physiological changes is crucial for managing health in malnourished individuals.

    Purpose of the Study:

    • To investigate adrenocorticoid activity in experimentally induced protein malnutrition in Rhesus monkeys.
    • To assess the impact of protein deficiency on plasma cortisol levels and diurnal rhythm.
    • To explore the relationship between protein malnutrition, hypoglycemia, and steroidogenesis.

    Main Methods:

    • Experimental induction of protein malnutrition in Rhesus monkeys.

    Related Experiment Videos

  • Control studies conducted in the same animals prior to malnutrition induction.
  • Measurement of plasma cortisol levels to assess adrenocorticoid activity and diurnal patterns.
  • Monitoring for fasting hypoglycemia.

    • Main Results:

    • Elevated plasma cortisol levels were observed in the protein-malnourished state.
    • Complete abolition of the diurnal rhythm of cortisol secretion occurred.
    • Fasting hypoglycemia was a consistent finding in protein-malnourished animals.
    • Sustained steroidogenesis was evident, indicating increased adrenocorticoid activity.

    Conclusions:

    • Protein deficiency leads to increased adrenocorticoid activity and sustained steroidogenesis in Rhesus monkeys.
    • Hypoglycemia, alongside metabolic stress, likely stimulates this heightened adrenocorticoid response.
    • Impaired defense against infections is a potential consequence of increased adrenocorticoid activity in protein-deficient hosts.