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Related Experiment Videos

Gender differences in learned helplessness behavior are influenced by genetic background.

B J Caldarone1, T P George, V Zachariou

  • 1Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 3rd Floor Research, New Haven, CT 06508, USA.

Pharmacology, Biochemistry, and Behavior
|September 6, 2000
PubMed
Summary

Learned helplessness behavior varies significantly between male and female mice, influenced by genetic background. These findings highlight the importance of considering both factors in research using this behavioral model.

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Area of Science:

  • Behavioral Neuroscience
  • Animal Models
  • Genetics

Background:

  • The learned helplessness model is crucial for studying stress-related disorders.
  • Genetic background and gender are known factors influencing behavior in mice.
  • Understanding these influences is vital for interpreting results from genetically modified mouse models.

Purpose of the Study:

  • To investigate learned helplessness behavior in different mouse genetic backgrounds and genders.
  • To determine the impact of genotype and sex on escape latencies in response to inescapable shock.

Main Methods:

  • Evaluated learned helplessness in female and male C57BL/6J, 129/J, (B6 x 129)F1, and outbred mice.
  • Utilized shuttlebox escape tasks following varying durations of inescapable shock.

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  • Compared escape latencies between shocked and nonshocked control groups across genotypes and sexes.

    • Main Results:

    • Outbred males exhibited increased escape latencies after shock, while outbred females did not.
    • C57BL/6J females showed increased latencies after 60, 120, or 360 shocks; males only after 360 shocks.
    • 129/J and (B6 x 129)F1 mice showed no significant differences, potentially due to baseline performance in controls.

    Conclusions:

    • Genetic background and gender significantly modulate learned helplessness behavior in mice.
    • These variables must be carefully considered when employing the learned helplessness model, especially in genetically manipulated mice.
    • Differences in escape performance were not attributable to variations in pain thresholds.