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Human T Lymphocyte Isolation, Culture and Analysis of Migration In Vitro
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Molecular characterization and leukocyte distribution of a teleost beta1 integrin molecule

Y Qian1, M Noya, A J Ainsworth

  • 1Department of Microbiology and Immunology, CB 7290, University of North Carolina, Chapel Hill, NC 27599, USA.

Veterinary Immunology and Immunopathology
|September 6, 2000
PubMed

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Activation of Integrins

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Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
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Immunoglobulin-like Cell Adhesion Molecules

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