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Developmental expression pattern of the cdo gene.

P J Mulieri1, A Okada, D A Sassoon

  • 1Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029, USA.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|September 7, 2000
PubMed
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The cell adhesion molecule CDO (cagiguanan homologue) is broadly expressed in developing mouse embryos, particularly in the central nervous system and sensory organs. Its restricted expression suggests a key role in cell determination and differentiation during vertebrate development.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • CDO (cagiguanan homologue) is a cell-surface protein involved in myogenic differentiation.
  • Understanding CDO's role in vertebrate development requires detailed expression pattern analysis.

Purpose of the Study:

  • To characterize the spatial and temporal expression pattern of CDO during mouse embryogenesis and rat brain development.
  • To infer the potential roles of CDO in vertebrate development based on its expression profile.

Main Methods:

  • Extensive in situ hybridization was employed to analyze CDO expression.
  • Expression was studied in mouse embryos from postimplantation to late stages.
  • Rat brain expression was examined from embryonic day 13 (E13) to adulthood.

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Main Results:

  • CDO exhibits broad, yet spatially and temporally restricted expression during embryogenesis.
  • Expression is detected early in the central nervous system (CNS), sensory organs (eye, ear), and in neural crest and mesodermal derivatives, including skeletal muscle precursors.
  • Highest expression levels were observed between E9.0 and E15.5, with increasing restriction in the adult CNS.

Conclusions:

  • The temporal onset and restricted expression patterns of CDO suggest its involvement in the determination and/or differentiation of various cell types.
  • CDO likely plays a significant role in vertebrate embryonic development, particularly in the CNS and sensory organ formation.