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Updated: Oct 13, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
[Chemotherapy for metastatic or recurrent laryngeal cancer: tolerance and early results]
A Kawecki1, B Jagielska, S Falkowski
1Klinika Nowotworów Głowy i Szyi, Centrum Onkologii w Warszawie.
Abstract:
In the Head and Neck Cancer Department of Cancer Centre in Warsaw between 1994 and 1998 fifty three patients with recurrent or metastatic laryngeal cancer were treated with methotrexate-based chemotherapy. Chemotherapy protocol consist of methotrexate, vinblastine, 5-fluorouracil, bleomycin, cyclophosphamide and steroids used every two weeks. Before treatment, unresectable local recurrence was observed in 35 patient and distant secondaries in 18 others. Tolerance of treatment was acceptable. Partial regression of the tumor was obtained in 30% of patients. Improvement of the quality of life was observed in 66%. Presented program is an effective alternative to supportive treatment in patients with recurrent or metastatic laryngeal cancer.
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