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Related Experiment Videos

[Sequential antibody determination in hepatitis E virus].

J H Vilar1, O A Soto Oca, N Pajor

  • 1Servicio de Clínica Médica, Hospital J.R. Vidal, Corrientes, Argentina. jovilar@arnet.com.ar

Acta Gastroenterologica Latinoamericana
|September 7, 2000
PubMed
Summary

This study identified acute herpes simplex virus encephalitis (HVE) in 18 of 24 patients using ELISA testing. Most positive results for acute HVE were confirmed approximately 60 days after symptom onset.

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Immunology

Context:

  • Herpes simplex virus encephalitis (HVE) is a severe neurological condition.
  • Early diagnosis is crucial for effective treatment and improved patient outcomes.
  • Diagnostic challenges exist in identifying acute HVE promptly.

Purpose:

  • To evaluate the diagnostic utility of a qualitative anti-HVE ELISA test for acute HVE.
  • To determine the time frame for detecting anti-HVE antibodies after symptom onset.
  • To characterize the clinical presentation of patients with presumptive HVE.

Summary:

  • Twenty-four patients with suspected HVE were tested using a qualitative anti-HVE ELISA.
  • Eighteen patients (75%) tested positive for acute HVE.

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  • The majority of positive results were detected around 60 days post-symptomatology, with clinical characteristics outlined.

    • Impact:

    • Highlights the potential of ELISA for HVE diagnosis.
    • Suggests a potential delay in serological confirmation of acute HVE.
    • Provides clinical insights into HVE presentation and diagnosis.