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Published on: September 22, 2020
[Coronary angioplasty in hemodialysis patients]
S Tabet1, C Le Feuvre, G Dambrin
1Service de cardiologie, hôpital Necker, Paris.
Insights
Coronary angioplasty with stenting is safe for hemodialysis patients, showing similar restenosis rates to controls. While mortality is higher in dialysis patients, it
Area of Science:
- Cardiovascular Medicine
- Nephrology
Background:
- Balloon coronary angioplasty has poor outcomes in hemodialysis patients due to high restenosis rates.
- The efficacy of coronary stenting in this population was previously unevaluated.
Purpose of the Study:
- To compare the outcomes of coronary angioplasty with stenting in hemodialysis patients versus a control group.
- To assess the safety and effectiveness of coronary angioplasty in hemodialysis patients.
Main Methods:
- A retrospective study comparing 63 coronary patients on hemodialysis with 63 matched controls.
- Analysis of primary success rate, early cardiovascular complications, restenosis rates, and mortality at two-year follow-up.
Main Results:
- No significant difference in primary angioplasty success (92% vs 89%) or early complications (4% vs 1.9%).
- Similar two-year restenosis rates (33% in hemodialysis vs 25% in controls).
- Higher two-year mortality in the hemodialysis group (15% vs 3.5%, p = 0.03), but lower than previously reported.
Conclusions:
- Hemodialysis does not increase restenosis risk following optimal coronary angioplasty (balloon or stenting).
- Coronary angioplasty, particularly with stenting, is a safe and effective revascularization strategy for hemodialysis patients with accessible lesions.
Abstract:
The results of balloon coronary angioplasty are very disappointing in haemodialysis patients because of the high restenosis rate. On the other hand, the use of stents in this population had not previously been assessed. This retrospective study compared 63 coronary patients on haemodialysis with a référence group of 63 paired patients with respect to gender, age, and the necessity or not of stent implantation. There was a higher frequency of hypertension (79 vs 39%) and of hypertriglyceridaema (22 vs 8%) in the haemodialysis group than in the controls. However, there was no significant difference with respect to primary success rate of angioplasty (92 and 89% respectively), nor to the development of early cardiovascular complications (4% and 1.9% respectively). After a two-year follow-up, there was no significant difference in the restenosis rate in the haemodialysis patients (33%) compared with the controls (25%). Nevertheless, the mortality rate at 2 years was higher in the dialysis group (15%) compared with the reference group (3.5%, p = 0.03). However, this mortality rate was lower than that reported in the literature in haemodialysis patients after balloon angioplasty. Therefore, haemodialysis does not increase the risk of restenosis when an optimal angiographic results is obtained either by balloon angioplasty or by angioplasty with stenting. Coronary angioplasty is a safe and effective method of revascularisation in coronary haemodialysis patients when the lesions are accessible to stenting.
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