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Bartter syndrome and focal segmental glomerulosclerosis: a possible link between two diseases
I H Su1, R Frank, B G Gauthier
1Division of Pediatric Nephrology, Schneider Children's Hospital of the North Shore-LIJ Health System, Albert Einstein College of Medicine, New Hyde Park, NY 11040-1432, USA.
Abstract:
We describe a patient with signs and symptoms of classic Bartter syndrome. The patient tested negative for all known genetic abnormalities associated with this tubular disorder. Proteinuria was found within 1 year after the diagnosis of Bartter syndrome. A renal biopsy performed 6 months later, when her kidney function was normal, revealed focal segmental glomerulosclerosis (FSGS). We propose a link between stimulation of the renin-angiotensin system and sclerotic changes in the glomerulus. This lesion may explain previous reports of kidney failure in patients with Bartter syndrome.