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Related Experiment Videos

Seminal plasma glycodelin and fertilization in vitro.

H Koistinen1, R Koistinen, C Hydén-Granskog

  • 1Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland.

Journal of Andrology
|September 7, 2000
PubMed
Summary

High levels of seminal plasma glycodelin may be linked to lower in vitro fertilization rates. However, glycodelin concentration alone has limited predictive value for fertilization success.

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Area of Science:

  • Reproductive Biology
  • Biochemistry

Background:

  • Glycodelin-A from the endometrium inhibits sperm-egg binding.
  • Seminal plasma glycodelin-S has differential glycosylation and does not inhibit binding.

Purpose of the Study:

  • To investigate the relationship between seminal plasma glycodelin concentration and in vitro fertilization (IVF) rates.
  • To determine if glycodelin-A glycosylation influences fertilization failure.

Main Methods:

  • Analysis of total glycodelin and glycodelin-A concentrations in seminal plasma.
  • Use of specific lectin-immunoassays to assess glycosylation patterns.
  • Logistic regression analysis combining glycodelin and sperm concentrations.

Main Results:

  • Total glycodelin levels were significantly higher in men with the lowest IVF rates.

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  • Combining glycodelin and sperm concentrations did not significantly improve prediction of low fertilization capacity.
  • No significant difference in glycodelin-A glycosylation was found between high and low fertilization groups.

    • Conclusions:

    • High seminal plasma total glycodelin shows a tendency towards association with lower IVF rates.
    • Glycodelin concentration alone has limited predictive value for in vitro fertilization success.