Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Progress in cancer gene therapy.

D T Curiel1, W R Gerritsen, M R Krul

  • 1Department of Medicine, Gene Therapy Center, University of Alabama, Birmingham 35294, USA.

Cancer Gene Therapy
|September 7, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ipilimumab with nivolumab in molecularly selected patients with castration-resistant prostate cancer: primary analysis of the phase II INSPIRE trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2024
Same author

The effects of new life-prolonging drugs for metastatic castration-resistant prostate cancer (mCRPC) patients in a real-world population.

Prostate cancer and prostatic diseases·2021
Same author

Health-related quality of life analysis in stage III melanoma patients treated with adjuvant dendritic cell therapy.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2018
Same author

Review: Effectiveness of implementation strategies to increase physical activity uptake during and after cancer treatment.

Critical reviews in oncology/hematology·2018
Same author

Augmented adenovirus transduction of murine T lymphocytes utilizing a bi-specific protein targeting murine interleukin 2 receptor.

Cancer gene therapy·2015
Same author

Gene therapy for radioprotection.

Cancer gene therapy·2015
Same journal

Transcriptomic profiling of a novel gastric implantation model identifies mechanisms and pathways that drive implantation into explanted human peritoneum.

Cancer gene therapy·2026
Same journal

NCBP1 promotes the malignant progression of Wilms' tumor through stabilization of KPNA2 mRNA.

Cancer gene therapy·2026
Same journal

Reprogramming the tumor microenvironment via TFF3 targeting: a potential novel avenue to boost CAR-T cell therapy in solid tumors.

Cancer gene therapy·2026
Same journal

Hepatitis B virus-induced hepatocellular carcinoma: HBx-associated epigenetic mechanisms and therapeutic opportunities.

Cancer gene therapy·2026
Same journal

Mesenchymal stem cell-mediated delivery boosts the efficacy of suicide gene therapy based on retroviral replicating vectors in peritoneally disseminated cancer.

Cancer gene therapy·2026
Same journal

The Tumor-suppressive role of CNTNAP2 in glioma: Dual regulation of the NDN-ERK axis and M2 macrophage polarization.

Cancer gene therapy·2026
See all related articles

Genetic anticancer agents are a rapidly developing field, with over 70% of clinical gene therapy trials focused on cancer treatment. A reassessment is underway to advance gene therapy for neoplastic diseases.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Gene therapy, initially for inherited diseases, is now predominantly used for cancer treatment.
  • Over 70% of human clinical gene therapy trials target neoplastic disorders.
  • The rationale for cancer gene therapy mirrors that for inherited disorders: understanding molecular basis, available therapeutic genes, and limited alternatives.

Framework:

  • The First International Symposium on Genetic Anticancer Agents convened to review progress.
  • Focus on preclinical and clinical gene therapy studies for cancer.
  • Discussion centered on the current state and future directions of gene therapy in oncology.

Implementation:

  • Gene therapy application in cancer leverages understanding of disease mechanisms.

Related Experiment Videos

  • Availability of therapeutic genes is crucial for treatment protocols.
  • Addressing the lack of effective alternative therapies drives gene therapy research.

    • Implications:

    • Recent successes in gene therapy for hemophilia and cardiovascular disease highlight its potential.
    • The current lack of realized clinical benefit for cancer necessitates a critical field reassessment.
    • This analysis aims to define pathways for advancing gene therapy to achieve its potential in treating cancer.