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Age-related decrease of the perineuronal satellite cell number in the rabbit spinal ganglia.

E Pannese1, M Ledda, C Martinelli

  • 1Institute of Histology, Embryology and Neurocytology, University of Milan, Italy.

Journal of the Peripheral Nervous System : JPNS
|January 1, 1997
PubMed
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Aging reduces the number of satellite cells in rabbit spinal ganglia, impacting neuronal support. This decrease contributes to age-related changes in the nerve cell sheath volume ratio.

Area of Science:

  • Neuroscience
  • Gerontology
  • Cell Biology

Background:

  • Age-related changes in spinal ganglia affect neuronal function.
  • Perineuronal glial sheaths and satellite cells play a role in neuronal support.

Purpose of the Study:

  • To determine if changes in perineuronal satellite cell number contribute to age-related volume ratio reductions in rabbit spinal ganglia.
  • To investigate the mechanisms behind satellite cell loss in aging rabbits.

Main Methods:

  • Estimation of nerve cell body volumes and satellite cell nuclei numbers from serial semithin sections.
  • Electron microscopy examination of satellite cell sheaths in young adult and old rabbits.

Main Results:

  • A significant decrease in mean satellite cell number was observed in aged rabbits compared to young adults.

Related Experiment Videos

  • Nerve cell bodies were significantly larger in aged rabbits.
  • Increased cytoplasmic vacuoles, connective tissue invaginations, and autophagic vacuoles were noted in older rabbits.

    • Conclusions:

    • Reduced satellite cell number is a key factor in the age-related decrease of the perineuronal glial sheath to nerve cell body volume ratio.
    • Satellite cell loss appears to occur partly through degeneration, with other mechanisms also possible.
    • The decline in satellite cell number likely negatively impacts neuronal activity.