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Intestinal iron absorption: current concepts circa 2000.

N C Andrews1

  • 1Howard Hughes Medical Institute, Division of Hematology/Oncology, Children's Hospital, Harvard Medical School, Boston, MA, USA.

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
|September 7, 2000
PubMed
Summary
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Iron is vital for red blood cell production, but excess iron is toxic. This review details how the small intestine regulates iron absorption after birth to maintain iron balance.

Area of Science:

  • Physiology
  • Biochemistry
  • Molecular Biology

Background:

  • Iron is an essential mineral for all mammalian cells, crucial for erythrocyte (red blood cell) haemoglobin production.
  • Maintaining iron homeostasis is critical, as both deficiency and excess iron can be toxic.
  • Regulation of iron levels occurs at entry points into the body, primarily the small intestine in adults.

Purpose of the Study:

  • To review the current understanding of molecular mechanisms governing intestinal iron absorption.
  • To provide an overview of the regulatory processes controlling dietary iron uptake.

Main Methods:

  • This review synthesizes existing research and literature on iron absorption.
  • Focuses on molecular and cellular mechanisms involved in intestinal iron transport.

Related Experiment Videos

Main Results:

  • Details the complex pathways of dietary iron absorption in the small intestine.
  • Highlights the critical role of specific proteins and transporters in iron uptake and regulation.

Conclusions:

  • Intestinal iron absorption is a tightly regulated process essential for maintaining systemic iron balance.
  • Recent advances have elucidated key molecular players, but further research continues to refine our understanding of iron homeostasis.