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Related Experiment Videos

Increased red cell distribution width and coeliac disease.

G Brusco1, M Di Stefano, G R Corazza

  • 1Gastroenterology Unit, University of Pavia, Italy.

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
|September 7, 2000
PubMed
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Elevated red cell distribution width is a frequent abnormality in coeliac disease patients. This finding suggests that increased red cell distribution width may serve as a new predictor for coeliac disease, prompting further antibody testing.

Area of Science:

  • Gastroenterology
  • Clinical Pathology
  • Immunology

Background:

  • Coeliac disease remains underdiagnosed despite available screening tests.
  • Identifying predictive hematochemical abnormalities is crucial for early diagnosis.
  • Adult coeliac disease diagnosis often relies on clinical presentation and serological markers.

Purpose of the Study:

  • To identify hematochemical abnormalities that are more predictive of coeliac disease in adults.
  • To evaluate the diagnostic utility of specific blood parameters in coeliac disease.
  • To investigate novel indicators for coeliac disease detection.

Main Methods:

  • Retrospective review of clinical records of 126 adult coeliac patients diagnosed since 1990.
  • Analysis of six hematochemical parameters: hemoglobin, red cell distribution width (RDW), serum iron, albumin, calcium, and potassium.

Related Experiment Videos

  • Statistical analysis (Chi-square) to compare the frequency of laboratory abnormalities.

    • Main Results:

    • Elevated red cell distribution width (RDW) was the most frequent hematochemical abnormality, observed in 57.9% of patients.
    • The prevalence of elevated RDW was statistically significant (p<0.01) compared to other laboratory changes.
    • Iron-deficiency anemia, a known indicator, was less frequent than elevated RDW in this cohort.

    Conclusions:

    • Increased red cell distribution width is a more common finding than iron-deficiency anemia in adult coeliac disease.
    • Elevated RDW can be considered a novel predictor for coeliac disease.
    • Presence of elevated RDW warrants investigation for coeliac disease, including antiendomysial antibody testing.