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Related Experiment Videos

Sex pili as immunogens.

H W Smith, M B Huggins

    Journal of General Microbiology
    |July 1, 1975
    PubMed
    Summary

    Vaccinating chickens with specific Escherichia coli strains carrying transfer factors F, I, or A2 influenced their immunity against Salmonella infections. Transfer factor F in E. coli K12 protected against F-plus Salmonella strains, while I-plus and A2-plus offered protection against I-plus Salmonella strains.

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    Area of Science:

    • Immunology
    • Microbiology
    • Veterinary Science

    Background:

    • Bacterial transfer factors play a crucial role in microbial interactions and immune modulation.
    • Understanding the specific roles of different transfer factors in host immunity is essential for developing effective vaccines.
    • Escherichia coli K12 strains with defined transfer factors offer a model system to study these interactions.

    Purpose of the Study:

    • To investigate the efficacy of vaccination with Escherichia coli K12 strains possessing specific transfer factors (F, I, A2) against Salmonella challenge in chickens.
    • To determine if transfer factor specificity influences the protective immune response.

    Main Methods:

    • Groups of chickens were vaccinated intravenously with live Escherichia coli K12 strains containing transfer factors F, I, A2, or no transfer factor (Tra-minus).
    • Immunity was challenged by intravenous injection with F-plus Salmonella heidelberg or F-plus/I-plus Salmonella typhimurium strains.
    • Mortality rates were compared between vaccination groups.

    Main Results:

    • Vaccination with the F-plus E. coli K12 strain significantly reduced mortality from F-plus Salmonella strains compared to the Tra-minus control.
    • Vaccination with I-plus or A2-plus E. coli K12 strains significantly reduced mortality from the I-plus Salmonella strain, but not the F-plus strain.
    • The F-plus E. coli K12 strain did not confer protection against the I-plus Salmonella strain.

    Conclusions:

    • Vaccination with specific transfer factor-bearing Escherichia coli K12 strains can induce a targeted immune response in chickens.
    • The protective effect of E. coli K12 vaccination against Salmonella is dependent on the specific transfer factor expressed by both the vaccine and the challenge strain.
    • This suggests a potential for developing transfer factor-specific vaccines for poultry.

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