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Inactive systemic lupus erythematosus id associated with a normal stimulated Th(1)/Th(2) cytokine secretory pattern
1Department "B" of Internal Medicine, Assaf Harofeh Medical Center, Zerifin, Israel. vazinam@post.tau.ac.il
Cytokine
|September 8, 2000
Abstract
Objectives:
To determine the Th(1)/Th(2)balance in systemic lupus erythematosus (SLE) patients with inactive disease.
Methods:
A comprehensive analysis of peak secretion, overall cytokine production and secretory pattern of Th(1)and Th(2)cytokines from stimulated PBMC of 10 SLE patients with inactive disease and 10 age- and sex-matched controls.
Results:
No significant differences were found in the peak and total secretion of all cytokines, as well as in the Th(1)and Th(2)secretory patterns and proliferative response between the two groups.
Conclusion:
Th(1)and Th(2) balance in inactive SLE is normal.