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Related Experiment Videos

Racial differences in ovarian cancer risk.

R B Ness1, J A Grisso, J Klapper

  • 1Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA.

Journal of the National Medical Association
|September 8, 2000
PubMed
Summary

African-American women have a lower risk of ovarian cancer, even after accounting for known risk factors. Differences in reproductive and gynecologic history may play a role, but don't fully explain the disparity.

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Area of Science:

  • Epidemiology
  • Oncology
  • Reproductive Health

Background:

  • Previous studies indicated a lower incidence of ovarian cancer among African-American women.
  • The reasons for this observed racial disparity in ovarian cancer risk were not fully understood.
  • Known risk factors for ovarian cancer include sociodemographic, reproductive, and physical characteristics.

Purpose of the Study:

  • To investigate if differences in known risk factors explain the lower ovarian cancer risk in African-American women compared to white women.
  • To compare risk and protective factors for epithelial ovarian cancer between racial groups.

Main Methods:

  • A population-based, case-control study was conducted.
  • Sociodemographic, reproductive, and physical risk factors were assessed in white and African-American women diagnosed with epithelial ovarian cancer (cases) and controls.

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  • Data from 669 white and 84 African-American cases were compared with 1110 white and 204 African-American controls.

    • Main Results:

    • African-American women reported higher rates of five or more pregnancies and hysterectomy.
    • White women were more likely to have a family history of ovarian cancer.
    • Despite these differences, ovarian cancer risk factors were similar between racial groups. African-American women had a significantly lower odds of ovarian cancer (OR 0.7, 95% CI 0.5-0.9), which persisted after adjusting for known risk factors (OR 0.8, 95% CI 0.6-1.0).

    Conclusions:

    • Ovarian cancer risk remains lower among African-American women compared to white women.
    • Differences in obstetric and gynecologic experiences may partially explain racial variations in ovarian cancer risk.
    • Further research is needed to elucidate the underlying reasons for the persistent lower risk in African-American women.