Related Experiment Video
Updated: Aug 16, 2026

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
Published on: September 25, 2017
[The probability of the carcinogenic risk of using nitrosomethylurea for treating cancer patients]
1N. M. Emanuel Institute of Biological Physics, Moscow.
Abstract:
The results of nitrosomethylurea (NMU) chemotherapy in 12 patients suffering Hodgkin's disease were evaluated. Significant effect was seen in 73.3% with 54.5% in complete remission. Out of 37 survivors for more than 5 years, 26 have survived tumor-free for 7-22 years. Secondary tumor disease (acute lymphoblastic leukemia) was diagnosed in one cases 14 years after diagnosis of Hodgkin's disease stage IIb, which was treated with radiation and standard chemotherapy, and 10 years after combination chemotherapy using NMU as a component for relapse. There is no evidence suggesting any risk of secondary tumor among NMU-treated cancer patients.
More Related Videos
Related Concept Videos
2° Amines to N-Nitrosamines: Reaction with NaNO2
Physical Properties of Amines
Mutagenicity and Carcinogenicity
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Two synthetic agonists of THC,...
Pharmacogenetics of Phase II Enzymes: N-acetyltransferase, Thiopurine S-methyltransferase, UDP-glucuronosyltransferase

