Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Cerebellar cortical abiotrophy in a beagle.

M Kent¹, E Glass, A deLahunta

¹School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.

The Journal of Small Animal Practice

|September 8, 2000

Summary

Neonatal cerebellar abiotrophy, a degenerative brain disorder, was diagnosed in a beagle puppy. This condition is likely an inherited genetic disorder passed through an autosomal recessive trait.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Rupture of the gastrocnemius muscle at its distal musculotendinous junction: conservative treatment and outcomes in 11 dogs.

New Zealand veterinary journal·2023

Same author

Neurodevelopmental scaling is a major driver of brain-behavior differences in temperament across dog breeds.

Brain structure & function·2021

Same author

Enriched environment exposure accelerates rodent driving skills.

Behavioural brain research·2019

Same author

Genotype-phenotype correlation in a large English cohort of patients with autosomal recessive ichthyosis.

The British journal of dermatology·2019

Same author

Contingency Training Alters Neurobiological Components of Emotional Resilience in Male and Female Rats.

Neuroscience·2018

Same author

Delayed asymptomatic progressive intraventricular pneumocephalus in a dog following craniotomy.

The Journal of small animal practice·2018

Area of Science:

Veterinary Neurology
Canine Genetics
Neurobiology

Background:

Neonatal cerebellar abiotrophy (NCA) is a group of inherited neurological disorders affecting the cerebellum.
Early diagnosis and understanding of genetic mechanisms are crucial for canine health management.

Observation:

A beagle puppy presented with clinical signs consistent with cerebellar dysfunction.
Cerebellar examination revealed diffuse degenerative cortical lesions.

Findings:

The clinical presentation and histopathological findings strongly suggest NCA in the affected puppy.
Breeding history supports a genetic basis, likely an autosomal recessive inheritance pattern for this canine neurological condition.

Implications:

This case highlights the importance of recognizing NCA in young dogs with neurological deficits.
Further genetic investigation could identify the specific mutation responsible for NCA in this beagle lineage.
Understanding the genetic transmission aids in responsible breeding practices to prevent hereditary neurological diseases in dogs.

Related Experiment Videos