Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelin: role in experimental hypertension.

E L Schiffrin1

  • 1MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montréal (IRCM), Quebec, Canada.

Journal of Cardiovascular Pharmacology
|September 8, 2000
PubMed
Summary

Endothelins (ET) may contribute to hypertension in rats, with elevated ET-1 in models of salt-sensitive hypertension. ET antagonism shows promise in treating vascular damage and improving heart failure in these models.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hypertension management in patients with renal cell cancer treated with anti-angiogenic agents.

Current oncology (Toronto, Ont.)·2012
Same author

Interleukin-2 enhances angiogenesis and preserves cardiac function following myocardial infarction.

Cytokine·2011
Same author

Radioligand binding assay.

Methods in molecular medicine·2011
Same author

Measurement of intracellular free calcium ion concentration in vascular smooth muscle cells : fluorescence imaging of cytosolic calcium.

Methods in molecular medicine·2011
Same author

Measurement of phospholipase d activation in vascular smooth muscle cells.

Methods in molecular medicine·2011
Same author

A novel and simplified method of culture of human blood-derived early endothelial progenitor cells for the treatment of ischemic vascular disease.

Cell transplantation·2011

Area of Science:

  • Cardiovascular Physiology
  • Endocrinology
  • Nephrology

Background:

  • The role of endothelins (ET) in blood pressure regulation and hypertension is debated.
  • Recent research suggests the ET system's involvement in various rat hypertension models.

Purpose of the Study:

  • To investigate the role of endothelin-1 (ET-1) in experimental hypertension in rats.
  • To explore the potential therapeutic effects of ET antagonism in hypertensive models.

Main Methods:

  • Analysis of preproendothelin-1 mRNA and peptide levels in vascular tissues of different hypertensive rat models.
  • Administration of ET antagonists to assess effects on blood pressure, vascular growth, and organ damage.

Main Results:

Related Experiment Videos

  • Increased ET-1 production observed in salt-sensitive hypertension models (DOCA-salt, Dahl salt-sensitive rats) and other models like stroke-prone SHR and angiotensin II-infused rats.
  • Some models, including SHR and L-NAME-treated rats, did not show increased ET-1.
  • ET antagonism led to reduced blood pressure and vascular growth regression in susceptible models.

    • Conclusions:

    • The ET system's involvement in hypertension appears linked to factors like high blood pressure severity, salt-sensitivity, and insulin resistance.
    • ET antagonism may offer benefits in managing vascular damage, stroke, renal failure, and heart failure in certain hypertensive conditions.
    • Further research is needed to confirm these findings in human hypertension.