Endothelin in cardiovascular disease: from atherosclerosis to heart failure

Area of Science:

• Cardiovascular Science
• Endocrinology
• Pharmacology

Background:

• Endothelin (ET) is a potent vasoconstrictor implicated in cardiovascular disease pathogenesis.
• ET influences vascular tone, cardiac hemodynamics, cellular proliferation, apoptosis, and matrix production.
• The endogenous ET system plays a significant role in both physiological and pathophysiological states.

Purpose of the Study:

• To elucidate the multifaceted role of endothelin in cardiovascular disease.
• To highlight the therapeutic potential of endothelin receptor antagonists.
• To deepen the understanding of the ET system's involvement in disease progression.

Main Methods:

• Review of existing evidence on endothelin's role in cardiovascular pathophysiology.
• Analysis of the development and application of endothelin receptor antagonists.
• Exploration of the mechanisms by which ET affects cellular and vascular functions.

Main Results:

• Endothelin contributes to cardiovascular diseases via multiple pathways.
• Endothelin receptor antagonists have emerged as valuable therapeutic agents.
• Studies on ET receptor antagonists enhance comprehension of the ET system in disease.

Conclusions:

• Endothelin is a key mediator in the development of cardiovascular diseases.
• Endothelin receptor antagonists represent a promising therapeutic avenue.
• Further research into the ET system is crucial for advancing cardiovascular disease treatment.