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Related Experiment Videos

Gallstones and gall bladder carcinoma.

L Vitetta1, A Sali, P Little

  • 1Graduate School of Medicine, Swinburne University, Hawthorn, Victoria, Australia. LVitetta@swin.edu.au

The Australian and New Zealand Journal of Surgery
|September 8, 2000
PubMed
Summary

Gallbladder cancer is linked to cholesterol gallstones, particularly large or numerous ones, in patients undergoing gallbladder removal surgery. This age-dependent cancer predominantly affects women with long-standing gallstone disease.

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Area of Science:

  • Gastroenterology
  • Surgical Oncology
  • Pathology

Background:

  • Gallbladder carcinoma is a rare but serious condition.
  • Cholecystectomy is a common procedure for gallstone disease.

Purpose of the Study:

  • To investigate the incidence of gallbladder carcinoma in patients who underwent cholecystectomy for gallstones.
  • To identify potential risk factors and associations between gallstones and gallbladder cancer.

Main Methods:

  • Retrospective review of demographical and clinical data.
  • Analysis of patients undergoing cholecystectomy and operative cholangiogram for gallstones.
  • Data collected from three major hospitals in northern Melbourne.

Main Results:

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  • Gallbladder carcinoma was found in 14 out of 439 patients (3.2%).
  • All cases of gallbladder carcinoma were associated with cholesterol gallstones, not pigment stones.
  • Carcinomas were more common in women (11 vs 3 men) with a median age of 78.5 years.

Conclusions:

  • Large or numerous cholesterol gallstones may contribute to gallbladder carcinoma development.
  • Chronic mechanical damage to the gallbladder mucosa by gallstones is a potential mechanism.
  • Gallbladder carcinoma is an age-dependent malignancy, often associated with long-standing gallstone disease, predominantly in women.