Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

The conserved exon method for gene finding.

V Bafna¹, D H Huson

¹Informatics Research, Celera Genomics Corp., Rockville, MD 20850, USA. Vineet.Bafna@celera.com

Proceedings. International Conference on Intelligent Systems for Molecular Biology

|September 8, 2000

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Oncogenic extrachromosomal DNA identification using whole-genome sequencing from formalin-fixed glioblastomas.

Annals of oncology : official journal of the European Society for Medical Oncology·2024

Same author

Multi-tissue proteogenomic analysis for mechanistic toxicology studies in non-model species.

Environment international·2023

Same author

Estimating the association between antibiotic exposure and colonization with extended-spectrum β-lactamase-producing Gram-negative bacteria using machine learning methods: a multicentre, prospective cohort study.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2019

Same author

Dynamics of the human gut phageome during antibiotic treatment.

Computational biology and chemistry·2018

Same author

CLUSEAN: a computer-based framework for the automated analysis of bacterial secondary metabolite biosynthetic gene clusters.

Journal of biotechnology·2009

Same author

Phylogenetic super-networks from partial trees.

IEEE/ACM transactions on computational biology and bioinformatics·2006

Same journal

Proceedings of the 8th International Conference on Intelligent Systems for Molecular Biology (ISMB 2000). San Diego, California, USA. August 19-23, 2000.

Proceedings. International Conference on Intelligent Systems for Molecular Biology·2001

Same journal

Analysis of gene expression data with pathway scores.

Proceedings. International Conference on Intelligent Systems for Molecular Biology·2000

Same journal

Towards a complete map of the protein space based on a unified sequence and structure analysis of all known proteins.

Proceedings. International Conference on Intelligent Systems for Molecular Biology·2000

Same journal

Mining for putative regulatory elements in the yeast genome using gene expression data.

Proceedings. International Conference on Intelligent Systems for Molecular Biology·2000

Same journal

A multiple alignment algorithm for metabolic pathway analysis using enzyme hierarchy.

Proceedings. International Conference on Intelligent Systems for Molecular Biology·2000

Same journal

Sequence database search using jumping alignments.

Proceedings. International Conference on Intelligent Systems for Molecular Biology·2000

See all related articles

A novel Conserved Exon Method (CEM) identifies gene structures by comparing DNA sequences for conserved protein regions. This approach simultaneously predicts genes in human and mouse genomes, showing promising results.

Area of Science:

Genomics
Bioinformatics
Computational Biology

Background:

Gene finding is crucial for understanding genome function.
Existing methods face challenges in accuracy and efficiency across species.

Purpose of the Study:

Introduce and evaluate the Conserved Exon Method (CEM) for gene prediction.
Develop a method for simultaneous gene structure prediction in related genomes.

Main Methods:

The Conserved Exon Method (CEM) identifies conserved protein sequences between DNA pairs.
Putative exon pairs are identified using conserved regions and splice junction signals.
Exon pairs are chained to predict complete gene structures.

Main Results:

Related Experiment Videos

The CEM approach was applied to human and mouse genomic sequences.

Experimental results demonstrate the method's potential utility in gene finding.

Simultaneous prediction across species was achieved.

Conclusions:

The Conserved Exon Method (CEM) offers a new strategy for gene prediction.
CEM shows promise for comparative genomics and gene structure identification.
Further validation may establish CEM as a valuable tool in bioinformatics.