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Genomic fold assignment and rational modeling of proteins of biological interest
1Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. M_Sauder@fccc.edu
Proceedings. International Conference on Intelligent Systems for Molecular Biology
|September 8, 2000
Abstract:
The first available genome of a multicellular organism, C. elegans, was used as a test case for protein fold assignment using PSI-BLAST, followed by rational structure modeling and interpretation of experimental mutagenesis data in the context of collaboration with biologists. Similar results are demonstrated for human disease proteins with known polymorphisms.