Related Experiment Video
Updated: Jun 30, 2026

Antibody Profiling by Luciferase Immunoprecipitation Systems (LIPS)
Published on: October 8, 2009
The antiphospholipid antibody syndrome.
1Mayo Clinic, Jacksonville, Florida 32224, USA.
Antiphospholipid syndrome is diagnosed by specific antibody elevations and thrombosis. Patients with unexplained retinal vascular disease may indicate this condition, highlighting the importance of ophthalmologic evaluation.
Area of Science:
- Ophthalmology
- Rheumatology
- Immunology
Background:
- Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by specific antibody levels and thrombotic events.
- Ocular involvement is a frequent manifestation of APS, impacting various parts of the eye.
Purpose of the Study:
- To highlight the association between antiphospholipid syndrome and retinal vascular disease.
- To emphasize the need for considering APS in patients with unexplained retinal vascular disease.
Main Methods:
- Review of diagnostic criteria for Antiphospholipid Syndrome.
- Analysis of clinical presentations of ocular manifestations in APS patients.
Main Results:
- Elevated lupus anticoagulant or anticardiolipin antibody titers, confirmed on two occasions 6 weeks apart, define APS.
- Retinal vascular disease in patients lacking typical risk factors suggests potential APS.
Conclusions:
- Ophthalmologists should consider Antiphospholipid Syndrome in patients presenting with retinal vascular disease without other identifiable causes.
- Early recognition of APS through ocular findings can lead to timely diagnosis and management, potentially preventing systemic complications.
More Related Videos
10:05Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate
Published on: January 17, 2018
10:31A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2
Published on: September 26, 2025
Related Concept Videos
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
Peripheral Artery Disease I: Introduction
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Hypersensitivity Reactions: Immune-Complex Reactions