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Synthesis of 7alpha-hydroxy derivatives of regulatory oxysterols
1Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA.
Steroids
|September 9, 2000
Abstract:
7alpha-Hydroxy derivatives of oxysterols are of considerable interest because of their possible involvement in regulation of cholesterol metabolism. This paper describes stereoselective syntheses and complete characterization of the 7alpha-hydroxy derivatives of four key oxysterols: 25-hydroxycholesterol, 27-hydroxycholesterol, 24(S)-hydroxycholesterol, and 24(S), 25-epoxycholesterol.